MEDPAGE TODAY reported: CKM framework validated in a cohort of 20-somethings.   

The relatively new concept of cardiovascular-kidney-metabolic (CKM) staging got further validation for young adults, based on a study in an urban population.

Among FF-CHAYA study participants followed from birth, the cardiovascular health scores in their early 20s fell in line with CKM staging (P<0.001). Scores on Life's Essential 8 averaged 77.6 in stage 0 (no risk factors), 70.0 in stage 1 CKM (excess adiposity), 63.8 in stage 2 CKM (metabolic risk factors), and 64.4 in stage 3 CKM (subclinical cardiovascular disease or advanced kidney disease).

In addition, CKM stages corresponded to early markers of carotid arterial injury in young adulthood. CKM stages 1-3 were associated with significantly higher mean-maximum carotid intima-medial thicknesses compared with stage 0, for instance, 0.014 mm thicker for stage 1, 0.020 mm thicker for stage 2, and 0.100 mm thicker for stage 3, reported Donald Lloyd-Jones, MD, ScM, of Boston University Chobanian & Avedisian School of Medicine, and colleagues in Circulation: Population Health and Outcomes.

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